Advancing human gut microbiota research by considering gut transit time (2023)

100 points
1/21/1970
a day ago
by mikhael

Comments


flossly

I did quite some experimenting with this.

Fruit moves fastest and green leaves. Meat, cheese, oil and fats slowest.

But we often eat combinations: and the slowest component of your food determines the speed of the whole.

Also: it's a one lane road and "over taking" is not possible.

So, eating a fast moving meal after a slow moving meal results in the fast mover getting stuck behind the slow mover.

Hence I start my day without and slow food (only fruit, herbs, green leaves, spices, ginger => usually a smoothy); and end the day with slow food (oily food, nuts, seeds, beans; usually combined with green leaves as we need a lot green leaves).

YMMV

a day ago

mrroryflint

There have been alternative (often mad) health proponents who have insisted upon only eating fruit in the morning for years - similar(ish) reasons. I think there is probably something to it.

a day ago

konradb

I remember this being a thing in some Tony Robbins book!

a day ago

sublinear

Whole fruit also has a lower glycemic index due to the fiber. This slow release of sugar helps reduce insulin resistance and balance out hormone response in general.

Hormonal imbalance is severely underrated as a root cause of common mental health issues like anxiety, depression, etc.

Having fruit in the morning is a little boost without the guilt. Adding in some light exercise, like walking, also helps prime the day. It even gets easier to wake up early for all this the more regularly it's done. It's one big reinforcement cycle for healthy habits.

a day ago

oulipo2

I mean the most obvious reason is fibers

a day ago

flossly

For me the most obvious reason is that we are primates and most primates have a fruit heavy diet. So I believe that's a reason for our human bodies to be very well adapted to fruit.

And that's the fibers, vitamins, minerals and sugars... The whole package.

a day ago

DANmode

Yeah, but during what part of the day do they eat it?! ^_^

11 hours ago

gchamonlive

Isn't slow food going through your body during sleep something that'll impact your sleep quality?

When you wake up you are basically fasting so your body is ready to take a hit. Slow food will go through your body faster when you eat it in the first half of your day.

a day ago

flossly

I found the same food goes about as fast (on a rather empty GI tract) no matter when eaten.

Slow food takes about 24h for me (so even when eaten early).

a day ago

gchamonlive

I don't think the last 12h impacts sleep quality that heavily though

a day ago

x______________

Interesting.

A great opportunity to add "YMMV"

a day ago

Ballas

Your Movements May Vary?

a day ago

anonu

YBMMV

a day ago

flossly

Did it!

a day ago

wantoncl

> Also: it's a one lane road and "over taking" is not possible.

I've eaten some hamburgers at Krystal's that definitely overtook whatever else was in front. Some folks have had the same or similar effect from White Castle, although I never have. Chipotle on occasion moves things along rather briskly too. No fruit or green leaves in any of them.

It may be that it's not a digestion thing, but some other factor they have that accelerates the process.

a day ago

Schmerika

Not a doctor but I know that some foods, in some guts, at some times can trigger a 'quick-release valve' of sorts. You're not digesting properly when that happens.

a day ago

_DeadFred_

This. Eject != digest

21 hours ago

boring-human

I don't disagree with your findings, but here's the model I use:

- Fiber: ^

- Dairy: v

- Coffee: ^^

- NSAIDs: vv

- Ice cream splurges: vvv

a day ago

arethuza

My breakfast routine for ~40 years has been coffee, muesli, coffee, yoghurt, coffee, fresh fruit all served with plenty coffee.

a day ago

sillyfluke

I end up eating a similar breakfast when I visit Swiss/Austrian/Dutch friends in their natural habitat.

a day ago

CTDOCodebases

Eating bitter greens can cause the body to secrete more bile and that speeds up fat digestion.

a day ago

Bender

I use TUDCA for that though it can make me gassy if I take too much.

a day ago

vogelke

> It's a one lane road and "over taking" is not possible.

Best poop-related comment I've seen.

a day ago

lordgrenville

n=1

But interesting nonetheless, thanks for sharing your findings.

a day ago

flossly

I have a small following of people how also saw improvements doing this.

Then, I did not come up with this myself, but found a lot of anecdotals in this direction.

And... I comment on a real science piece that seems to be making similar claims.

a day ago

andsoitis

Have you found that coffee speed things up?

a day ago

flossly

I cannot stand the taste coffee. So no data from my side.

a day ago

sublinear

I have, but I think any stimulant would do similar. I no longer smoke, but that did it too.

a day ago

paul7986

For me i drink close to a gallon of water a day and that truly cleans me out daily.

a day ago

calf

Just to be clear I thought the typical advice has been fiber -> protein -> carbs, for blood sugar reasons, you're saying to frontload fiber/carbs & backload proteins for easier digestion? That is interesting, I wonder what studies there are on this.

a day ago

flossly

My reason is I dont want the fast moving food to get stuck behind the slow moving food.

Another reason I do it like this: I get no after diner dip from fast moving food. Slow moving food makes me crash a little, and I prefer to experience that in the evenings.

I did also experiments with fruit (and leaves) only diets. No crashes at all. Nice! But I did crave savory, chewy food a lot.

a day ago

senectus1

yeah my mileage is i eat fruit and i get cramps and the squirts for the next two days.

as I've gotten older my ability to consume fruit, onions, garlic and most dairy (and coffee :-( ) has been taken away from me. its really a miserable experience for someone that enjoys eating new and interesting things all the time.

a day ago

asplake

IANAD, but sounds like IBS or similar, not necessarily age-related, and potentially treatable.

a day ago

g8oz

Look into the low FODMAP diet.

a day ago

altmanaltman

What do you mean, the human stomach is absolutely not a "one line road", your comments lacks the basic biological understanding. What you're describing is a good generic diet and maybe that's why it feels good but please learn a bit more about the stuff you are expetimenting on.

a day ago

flossly

I did not mention stomach. I meant the GI-tract as a whole.

I've used food coloring and indigestibles (like corn kernels) to do experiments on whether meals can "overtake" or "merge" or "join" with other meals into poops.

a day ago

aziaziazi

I'd love to read more about your experiments, please don't refrain from writing about it someday.

19 hours ago

jahller

that's the most insane thing i read today. kudos to your curiosity

a day ago

andrewf

Then you'll love https://onlinelibrary.wiley.com/doi/full/10.1111/jpc.14309

"Six paediatric health-care professionals were recruited to swallow a Lego head."

a day ago

red-iron-pine

omg this article is wild lol

> To standardise bowel habit between participants, we developed a Stool Hardness and Transit (SHAT) score to look at stool consistency over time. The SHAT score is the sum of the Bristol Stool Chart scores over a specific time period divided by that time period in days.

> Post-ingestion, stools were monitored and examined in search of the excreted item. The search was conducted on an individual basis, and search technique was decided by the participant. The primary outcome was the Found and Retrieved Time (FART) score.

a day ago

flyinglizard

Adding debug prints to your diet.

a day ago

altmanaltman

Food coloring is a liquid dye. It will mix with whatever chyme it encounters in the stomach and small intestine, dyeing a large portion of the stool. It does not prove that food stayed in a single-file line.

Also, again the GI-tract as a whole is also not a "one-lane road".

Please educate yourself and do not do "experiments" on yourself. A good place to start learning more would be: https://accessmedicine.mhmedical.com/book.aspx?bookid=691 if you're intrested.

a day ago

IAmBroom

You are very judgey and controlling. Maybe some prune juice would help?

a day ago

SideburnsOfDoom

I will add an anecdote that from observation, two people on the same diet over long periods can have significantly different poop frequencies, and differing regularity.

YMMV. It's not just determined by the food intakes, there are individual factors.

At a guess, these individual factors start with 1) genetic component to reactions to substances such as lactose and to caffeine. 2) Gut microbiome.

In other words, saying "change diet and you can change the poop schedule" is true, but "with this diet you will definitely get this schedule" is not.

a day ago

alpineman

Or just don't eat meat and cheese at all

a day ago

flossly

I've not for the last 12 years. But fake meats/dairies have a very similar macro profile, so I expect them to digest similarly.

I'll not try though, as I'm vegan for ethical reasons.

a day ago

mcv

Better for the environment too.

a day ago

flyinglizard

The best thing for the environment is dying. You stop wasting resources and start fertilizing the soil.

a day ago

danielbln

Only a Sith deals in absolutes.

a day ago

mplanchard

The article is open access, I don’t see any reason to prefer the dumbed-down narrative summary: https://gut.bmj.com/content/72/1/180

a day ago

dustractor

This is why I suspect that GLP-1 agonist medications have the potential to cause a cascade of negative consequences for the health of some people. One of the mechanisms is slowed gastric emptying which leads to decreased motility of the small intestine as a side effect. They do tell people to drink more water to counteract this. It just seems like trading one set of problems for another so hopefully doctor and patient will carefully weigh the benefits versus the risks. We shall see.

a day ago

the_real_cher

I got food poisoning on a GLP-1 and the slowed gastric emptying made it a hellish 5 days.

a day ago

sph

I guess with my IBS I should be the healthiest person around.

a day ago

adt

Akshually, IBS-D is the least common form of IBS.

https://pmc.ncbi.nlm.nih.gov/articles/PMC3865067/

a day ago

fibermaxxx

More fiber, more plants. I know individuals that eat "only vegetable on the burger" Oats, grits, or smoothie for early day Mine:Fruit smoothie with oats Starches, leafy greens, for midday Mine:roasted sweet potato on a salad Legumes and tree nuts for dinna Mine:Chickpea sauce over roasted veggies with pasta, or cashews.

The goal is more than 13 plants a day and your movement will be very consistent

a day ago

jonatron

I'm surprised there's no mention of hot drinks in the morning.

a day ago

iszomer

Consumption of dairy and products are a relatively fast and painful solution for personal system purges within 30m but entirely depends on how processed they are.

a day ago

DaedalusII

you may evaluate the concept of a milk enema, dramatic and rapid defecation ensues in comparison to a saline enema

a day ago

iszomer

At that point it’s less of an ‘enema’ and more like udder chaos.

19 hours ago

cess11

https://gut.bmj.com/content/72/1/180

The study. It basically says that this is something one perhaps should consider in clinical settings and that the speed of fecal matter might be a worthwhile direction for future inquiry.

"Altogether, a better understanding of the complex, bidirectional interactions between the gut microbiota and transit time is required to better understand gut microbiome variations in health and disease."

It does not say 'this is a sign of health and that is not'.

a day ago

deepsun

"Linked" not "caused". So it may be that someone with Parkinson's just happen to have slower rates.

a day ago

Qem

I wonder if this explains in part the purported health benefits from cofee. One thing people claim makes hard to quit cofee habit it's that they can't take a shit in the morning anymore.

a day ago

devolving-dev

I wonder what this means for GLP 1 drugs that slow digestion.

a day ago

andreareina

Actual outcome data shows that they're a net benefit, and it's not even close.

a day ago

[deleted]
a day ago

hhh

And if I flip flop between both?

a day ago

nacozarina

stress-induced

nobody dumps during their first two days of boot camp

a day ago

phyzix5761

I wonder how Ozempic affects this because it slows down gastric emptying.

a day ago

[deleted]
a day ago

beardyw

If the writer ingested a lot, very little came out.

a day ago

fellowniusmonk

I've been using 1/4cup ground hulled barley and 20-32oz of greek yogurt, with a bit of craisins and pecans as my base for the last several years, my gut now chews through everything and output is consistent and homogeneous.

You gotta lay down a fermentation base.

a day ago

pawelduda

Sooo.... Another reason to drink coffee/yerba mate? Although the latter also supposedly stimulates release of GLP1, which slows down "the release"

a day ago

feverzsj

Eat lots of fibers and water, and you'll poop like a cow.

a day ago

iammjm

... Would that be good? I mean that soft flat pancake thing they produce. My general approach so far was to aim fora not too soft, not too hard kind of poop. Like a one that slides out of you with minimal wiping needed afterward. Like what would be the gold standard for poop consistency?

a day ago

Grp1

this post needs an enema

a day ago

bregma

I find I can't keep it down for more than a few minutes. I guess I can eat all the poop I want and stay healthy then?

a day ago

sans_souse

[flagged]

a day ago

delis-thumbs-7e

In that case you really should go and see a doctor ASAP.

a day ago

fny

Headline is megaclickbait. The research is about how healthier gut microbiomes correlate with improved pooping and nothing about how it impacts your health.

a day ago

mplanchard

From the article’s “key takeaways”:

> By considering interindividual and intraindividual differences in transit time in human studies, diet–microbiota interactions and disease-related microbiome signatures may be better elucidated.

There is also an entire section entitled “The role of gut transit time in health and disease”

a day ago

fny

None of this is summarized in the posted article. It's in the research paper which I didn't read because the article seemed like fluff.

a day ago

mplanchard

Seems presumptuous to make assertions about what’s in the research if you haven’t read it

20 hours ago